ARYLHYDROXAMIC ACID N,O-ACYLTRANSFERASE - APPARENT SUICIDE INACTIVATION BY CARCINOGENIC N-ARYLHYDROXAMIC ACIDS

Carcinogenic arylhydroxamic acids (N-hydroxy-2-acetylamino-fluorene, N-hydroxy-4-acetylaminobiphenyl, and trans-N-hydroxy-4-acetyl-aminostilbene) are irreversible inhibitors of rat and hamster hepatic N,O-acyltransferase. The kinetic characteristics of this inhibition are consistent with suicide inactivation of the enzyme. This finding appears to be the first example of carcinogens serving as suicide substrates for an enzyme system which is responsible for their bioactivation. © 1979.