BRADYKININ STIMULATES THE PRODUCTION OF PROSTAGLANDIN-E2 AND INTERLEUKIN-6 IN HUMAN OSTEOBLAST-LIKE CELLS

被引：39

作者：

RAHMAN, S

BUNNING, RAD

DOBSON, PRM

EVANS, DB

CHAPMAN, K

JONES, TH

BROWN, BL

RUSSELL, RGG

机构：

[1] Department of Human Metabolism and Clinical Biochemistry, University of Shetfield Medical School, Sheffield

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1992年 / 1135卷 / 01期

关键词：

BRADYKININ; ARTHRITIS; INFLAMMATION; OSTEOBLAST-LIKE CELL; PROSTAGLANDIN-E2; INTERLEUKIN-6; INTERLEUKIN-1; (HUMAN);

D O I：

10.1016/0167-4889(92)90172-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of bradykinin (BK) on proteinase activity, prostaglandin synthesis, and the production of interleukin-6 (IL-6) was investigated in cultures of human osteoblast-like cells. Bradykinin had no effect on stromelysin activity and plasminogen activator activity produced by human osteoblast-like cells. However, BK stimulated the production of prostaglandin E2, an effect that was markedly enhanced by pre-incubation with recombinant interleukin-1 alpha (rhIL-1-alpha), but was apparently unaffected by BK receptor antagonists types 1 and 2. Bradykinin stimulated the intracellular accumulation of total inositol phosphates suggesting that its effects were mediated by stimulation of phosphoinositide metabolism. Bradykinin within the dose range of 10(-11)-10(-5) M also significantly stimulated the production of IL-6. Bradykinin may, therefore, mediate a variety of responses in bone under both physiological and pathological conditions.

引用

页码：97 / 102

页数：6

共 35 条

[1] PRODUCTION OF HYBRIDOMA GROWTH-FACTOR BY HUMAN-MONOCYTES [J].