ASSOCIATION BETWEEN EXPRESSION OF IMMUNOGLOBULIN G-BINDING PROTEINS BY GROUP-A STREPTOCOCCI AND VIRULENCE IN A MOUSE SKIN INFECTION MODEL

In this study, we developed a mouse model of skin infection to test the association between expression of immunoglobulin-binding proteins by and infectivity of group A streptococci. Group A streptococci capable of crossing tissue barriers and establishing a lethal systemic infection in ice showed a higher level of immunoglobulin-binding protein expression. The group A streptococci recovered from the spleen of a mouse that died following a skin infection were found to be more virulent when injected into the skin of naive mice. Together, these results suggest that immunoglobulin-binding protein expression by group A streptococci correlates with their ability to establish invasive skin infections.