ADENOPHOSTIN-A AND ADENOPHOSTIN-B - POTENT AGONISTS OF INOSITOL-1,4,5-TRISPHOSPHATE RECEPTOR PRODUCED BY PENICILLIUM-BREVICOMPACTUM - TAXONOMY, FERMENTATION, ISOLATION, PHYSICOCHEMICAL AND BIOLOGICAL PROPERTIES

被引：104

作者：

TAKAHASHI, M

KAGASAKI, T

HOSOYA, T

TAKAHASHI, S

机构：

[1] SANKYO CO LTD,FERMENTAT RES LABS,2-58 HIROMACHI,1-CHOME,SHINAGAWA KU,TOKYO 140,JAPAN

[2] SANKYO CO LTD,TSUKUBA RES LABS,TSUKUBA,IBARAKI 305,JAPAN

来源：

JOURNAL OF ANTIBIOTICS | 1993年 / 46卷 / 11期

关键词：

D O I：

10.7164/antibiotics.46.1643

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

New inositol-1,4,5-trisphosphate (InsP3) agonists, adenophostins A(1) and B(2), were isolated from the culture broth of Penicillium brevicompactum SANK 11991 and SANK 12177. Its structures were related to adenine nucleotides. The agonistic activity of adenophostins A or B for binding to the InsP3 receptor was higher than InsP3 itself.

引用

页码：1643 / 1647

页数：5

共 7 条

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