HIGHLY REGIOSELECTIVE NUCLEOPHILIC-SUBSTITUTION OF CYCLIC CARBONATES OF THREO-2,3-DIHYDROXY ESTERS - SYNTHESIS OF OPTICALLY PURE BETA-HYDROXY ESTERS

被引：13

作者：

KANG, SK

PARK, DC

RHO, HS

YOON, SH

SHIN, JS

机构：

[1] Department of Chemistry, Sung Kyun Kwan University, Natural Science Campus

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 24期

关键词：

D O I：

10.1039/p19940003513

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The nucleophilic ring opening of the cyclic carbonates of optically active threo-2,3-dihydroxy esters 1 afforded the alpha-substituted beta-hydroxy esters 2 with highly regio- and stereo-selectivity under mild conditions. The alpha-sulfanyl or alpha-iodo beta-hydroxy esters 2 thus obtained were transformed to the beta-hydroxy esters 3, which are useful chiral synthons' for natural product synthesis.

引用

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页码：3513 / 3514

页数：2

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