PARTIAL SEQUENCES OF 6 MACROGLOBULIN LIGHT CHAINS . ABSENCE OF SEQUENCE CORRELATES TO FUNCTIONAL ACTIVITY

被引：19

作者：

KAPLAN, AP

METZGER, H

机构：

[1] National Institute of Arthritis and Metabolic Diseases, National Institutes of Health, Bethesda

来源：

BIOCHEMISTRY | 1969年 / 8卷 / 10期

关键词：

D O I：

10.1021/bi00838a010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The amino acid sequence of portions of the variable regions of the light chains from six Waldenstrom macroglobulins has been determined. Four of the six proteins studied show evidence of binding activity. No distinctive sequences which correlated with the functional properties of the active proteins were observed. The data also strengthen previous evidence that light chains associated with μ-type heavy chains are not as a group distinguishable from those associated with other heavy-chain classes. © 1969, American Chemical Society. All rights reserved.

引用

页码：3944 / &

共 32 条

[1]

ASHMAN RF, 1969, J BIOL CHEM, V244, P3405

[2]

BENNETT JC, 1967, METHOD ENZYMOL, V11, P330

[3] STRUCTURE OF ANTIBODY COMBINING SITE .I. HAPTEN STABILIZATION OF ANTIBODY CONFORMATION [J].