CONTROL OF CEREBRAL EDEMA BY TOTAL HEPATECTOMY AND EXTRACORPOREAL LIVER SUPPORT IN FULMINANT HEPATIC-FAILURE

被引：127

作者：

ROZGA, J ^{[1
]}

PODESTA, L ^{[1
]}

LEPAGE, E ^{[1
]}

HOFFMAN, A ^{[1
]}

MORSIANI, E ^{[1
]}

SHER, L ^{[1
]}

WOOLF, GM ^{[1
]}

MAKOWKA, L ^{[1
]}

DEMETRIOU, AA ^{[1
]}

机构：

[1] CEDARS SINAI MED CTR,LIVER SUPPORT UNIT,8700 BEVERLY BLVD,LOS ANGELES,CA 90048

来源：

LANCET | 1993年 / 342卷 / 8876期

关键词：

D O I：

10.1016/0140-6736(93)91947-K

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Keeping a patient with fulminant hepatic failure (FHF) alive until a donor liver is available for transplantation can be a problem. We describe an 18-year-old woman with paracetamol-induced FHF, who was treated by total hepatectomy, hypothermia, plasma exchange, and extracorporeal liver support. The patient was anhepatic for 14 h. The liver-support system consisted of plasma separation and perfusion through a charcoal filter and a hollow-fibre module seeded with matrix-attached porcine hepatocytes. With artificial liver treatment there was reversal of severe neurological dysfunction, normalisation of intracranial pressure, and decreased serum ammonia. The patient underwent emergency transplantation with an ABO-incompatible liver, followed by transplantation with a compatible organ eight days later. The patient has fully recovered and is neurologically intact.

引用

页码：898 / 899

页数：2

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