CHOLERETIC RESPONSE TO FEEDING IN DOGS

Mongrel dogs were prepared by cholecystectomy, ligation of the lesser pancreatic duct, and insertion of a Thomas cannula into the duodenum opposite the opening of the common bile duct. The common bile duct was cannulated through the duodenal cannula and bile flow and composition were observed after feeding graded quantities of canned dog food. The magnitude of the choleresis was dependent upon and linearly related to the logarithm of the quantity of food eaten. Multiple feeds did not produce greater peak 15-min bile flow or hourly bile flow than a single feed of an equal amount of food. After feeding bicarbonate and chloride, concentration in bile increased as bile flow increased. The relationships between volume, chloride concentration, and bicarbonate concentration of the calculated “electrolyte fraction” during feeding choleresis were similar to those seen during secretin choleresis. This work was supported by Veterans Administration research funds and by National Science Foundation Grant GB 7285X. The authors are grateful for the expert technical assistance of Mr. John Washington. © 1969, SAGE Publications. All rights reserved.