TRISOMY-2 AND TRISOMY-20 IN 2 HEPATOBLASTOMAS

被引：22

作者：

SOUKUP, SW ^{[1
]}

LAMPKIN, BL ^{[1
]}

机构：

[1] CHILDRENS HOSP MED CTR RES FDN, DIV HEMATOL ONCOL, CINCINNATI, OH 45229 USA

来源：

GENES CHROMOSOMES & CANCER | 1991年 / 3卷 / 03期

关键词：

D O I：

10.1002/gcc.2870030310

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytogenetic analysis of two pediatric hepatoblastomas is presented, comparing results in primary tumor samples, nude mouse xenographs, and lung metastases in one case. Both tumors had trisomy 2 and 20 in the primary tumors, along with other structural abnormalities. In subsequent passages/metastases, both tumors showed structural changes in one chromosome 2, resulting in partial trisomy 2q, along with structural changes of other chromosomes. Partial trisomy 1q was also common to both tumors in late stages. Results are compared to those of embryonal rhabdomyosarcoma, where trisomy 2 has also been noted.

引用

页码：231 / 234

页数：4

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