CYCLOHEXIMIDE INHIBITS LIGHT-INDUCED PHASE-SHIFTING OF THE CIRCADIAN CLOCK IN NEUROSPORA

被引：26

作者：

JOHNSON, CH

NAKASHIMA, H

机构：

[1] Department of Biology, Vanderbilt University, Nashville, Tennessee, Box 1812, Station B

[2] Division of Chronobiology, National Institute for Basic Biology, Myodaijicho

来源：

JOURNAL OF BIOLOGICAL RHYTHMS | 1990年 / 5卷 / 02期

关键词：

D O I：

10.1177/074873049000500207

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cycloheximide inhibits light-induced phase shifting of the circadian clock and protein synthesis in Neurospora. Light resetting is not inhibited in mutants whose protein synthesis is resistant to cycloheximide. When light and cycloheximide are presented together at various circadian phases, the final phase shift is always determined by cycloheximide. This dual-treatment phase response curve approach may be useful for other studies using pharmacological treatments to analyze clock pathways. Taken together, the results suggest that synthesis of a protein (or proteins) is involved in the photo- transduction pathway of the circadian clock in Neurospora. © 1990, Sage Publications. All rights reserved.

引用

页码：159 / 167

页数：9

共 25 条

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