ASYMMETRIC-SYNTHESIS OF ALPHA-ALKYLATED ALPHA-AMINO-ACIDS - AZEPANE-2-CARBOXYLIC ACIDS

被引：9

作者：

GEORG, GI

GUAN, XM

KANT, J

机构：

[1] Department of Medicinal Chemistry, University of Kansas, Lawrence

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1991年 / 1卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(00)80245-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of optically active alpha-alkylated azepane-2-carboxylic acid esters 3 was achieved via Schmidt rearrangement of optically active ethyl 2-oxo-1-alkyl-cyclohexanecarboxylates 1 followed by selective reduction of the amide carbonyl group.

引用

页码：125 / 128

页数：4

共 25 条

[1]

Barrett G.C., 1985, CHEM BIOCH AMINO ACI, P246

[2]

BARRETT GC, IN PRESS TETRAHEDRON, V33

[3] SELECTIVE REDUCTIONS .29. A SIMPLE TECHNIQUE TO ACHIEVE AND ENHANCED RATE OF REDUCTION OF REPRESENTATIVE ORGANIC-COMPOUNDS BY BORANE-DIMETHYL SULFIDE [J].