HEPARIN-COATED CARDIOPULMONARY BYPASS CIRCUITS REDUCE BLOOD-CELL TRAUMA - EXPERIMENTS IN THE PIG

被引：45

作者：

THELIN, S

BAGGE, L

HULTMAN, J

BOROWIEC, J

NILSSON, L

THORELIUS, J

机构：

[1] Departments of Cardiovascular and Thoracic Surgery, Uppsala

[2] Anaesthesiology, University Hospital, Uppsala

来源：

EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY | 1991年 / 5卷 / 09期

关键词：

BLOOD TRAUMA; CARDIOPULMONARY BYPASS; HEPARIN SURFACE COATING; OXYGENATOR; PLATELETS;

D O I：

10.1016/1010-7940(91)90145-A

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Blood cell trauma and postoperative bleeding remain important problems in cardiopulmonary bypass (CPB). We compared heparin-coated with non-coated circuits in the pig. Twenty animals were perfused for 2 h at normothermia using membrane oxygenators (Bentley Bos 50). Two groups were studied. In the non-coated group (NC, n = 11) the CPB circuits used were without a heparin coating. This group had systemic heparinization of 400 IU/kg to maintain an ACT (activated clotting time) of over 400 s during CPB. In the coated group (C, n = 9), all surfaces exposed to blood in the CPB circuits were heparin-coated 1. This group had the heparin dose reduced to 25% (100 IU/kg) without further administration regardless of ACT. During CPB, group C displayed shorter ACT (per definition), higher platelet count, platelet adhesion and lower fibrinolysis and haemolysis (P < 0.05) as compared to group NC. No thromboembolic events were detected during CPB. Three animals in group NC and 4 animals in group C were weaned from CPB and protaminized. Four hours postoperatively, the leucocyte consumption was two-fold greater and blood loss four-fold greater in group NC as compared with group C (P < 0.05). Perfusion with heparin-coated surfaces reduces blood cell trauma. The decreased postoperative blood loss observed in group C is probably explained by the reduced dosages of heparin and protamine.

引用

页码：486 / 491

页数：6

共 17 条

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