CHROMOSOME ERRORS AT MITOTIC ANAPHASE

被引:26
作者
FORD, JH
CORRELL, AT
机构
[1] Genetics Department, Queen Elizabeth Hospital, Woodville
关键词
NONDISJUNCTION; LAGGING; INSITU; SATELLITE DNA; ANEUPLOIDY;
D O I
10.1139/g92-107
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Errors in mitotic divisions were assayed using various satellite DNAs as probes, hybridized in situ, to show that they included nondisjunction, chromosome and chromatid Iagging, chromatid malsegregation, and monopolar segregations. The total rates of error were 1.7, 1.1, and 0.6% for chromosomes X, 17, and 18, respectively. Lagging was the most common error for all chromosomes and chromatid malsegregation, a source of 3:1 segregations occurred at about the same frequency as nondisjunction. In some cells, lagging of both X chromatids occurred and there were several cells where both X chromosomes showed errors in segregation. The disjunction of chromosomes was shown to be independent of their segregation and is speculated to involve a different mechanism.
引用
收藏
页码:702 / 705
页数:4
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