SEQUENTIAL ALTERATIONS IN TRANSFER-RNA POPULATION OF 2-ACETYLAMINOFLUORENE-INDUCED HEPATOCYTE NODULES

被引：13

作者：

KANDUC, D ^{[1
]}

FARBER, E ^{[1
]}

GHOSHAL, A ^{[1
]}

NAGAI, M ^{[1
]}

机构：

[1] UNIV BARI,FAC SCI,DEPT BIOCHEM & MOLEC BIOL,I-70126 BARI,ITALY

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 195卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.2186

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to investigate the possible mechanisms by which cellular alterations can start an altered onco-developmental gene expression, we studied tRNA distribution profiles during the early steps of 2-acetylaminofluorene-induced hepatocarcinogenesis. The finding of progressive and sequential alterations appears to support the hypothesis of a causal connection between tRNA changes and nodular cell proliferation, possibly through the disruption of the mechanism which regulates tRNA functional adaptation. © 1993 Academic Press, Inc.

引用

页码：1309 / 1313

页数：5

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