NOVEL BIOACTIVE DITERPENOIDS FROM AFRAMOMUM-AULACOCARPOS

被引：34

作者：

AYAFOR, JF

TCHUENDEM, MHK

NYASSE, B

TILLEQUIN, F

ANKE, H

机构：

[1] UNIV PARIS 05, FAC PHARM, DEPT PHARMACOGNOSY, CNRS, URA 3010, F-75006 PARIS, FRANCE

[2] UNIV KAISERSLAUTERN, DEPT BIOTECHNOL, W-6750 KAISERSLAUTERN, GERMANY

来源：

JOURNAL OF NATURAL PRODUCTS | 1994年 / 57卷 / 07期

关键词：

D O I：

10.1021/np50109a007

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Three new labdane diterpenes, 12 alpha, 17-epoxy-3 beta-hydroxy-8(9),13-labdadien-16,15-olide (aulacocarpinolide) [1], methyl 8 beta,17:14 zeta,15-diepoxy-3 beta-hydroxy-12E-labden- 16-oate (aulacocarpin A) [2],and methyl 8 beta,17:14 zeta,15-diepoxy-3 beta,6 beta-dihydroxy-12E-labden-16-oate (aulacocarpin B) [3] have been isolated from the Cameroonian spice, Aframomum aulacorpos, and their structures elucidated using spectroscopic techniques. The known bioactive diterpene dialdehyde, 8 beta,17-epoxy-12E-labdene-15,16-dial (aframodial) [4] was also isolated. Compounds 1-3 showed weak antimicrobial and cytotoxic activities.

引用

页码：917 / 923

页数：7

共 10 条

[1] ASSAYS OF THE BIOLOGICAL-ACTIVITIES OF GUAIANE SESQUITERPENOIDS ISOLATED FROM THE FRUIT BODIES OF EDIBLE LACTARIUS SPECIES [J].