GLUTAMATERGIC EXCITATORY RESPONSES OF ANTERIOR CINGULATE NEURONS TO STIMULATION OF THE MEDIODORSAL THALAMUS AND THEIR REGULATION BY GABA - AN INVIVO IONTOPHORETIC STUDY

被引:53
作者
GIGG, J
TAN, AM
FINCH, DM
机构
[1] UNIV CALIF LOS ANGELES, INST BRAIN RES, LOS ANGELES, CA 90024 USA
[2] UNIV CALIF LOS ANGELES, REED NEUROL RES CTR, DEPT NEUROL, LOS ANGELES, CA 90024 USA
关键词
D O I
10.1093/cercor/2.6.477
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Anatomical and physiological studies in the rat have shown projections from the medial dorsal thalamus to the anterior cingulate cortex. We used multibarrel iontophoresis to identify the neurotransmitter used in this thalamic projection. Extracellular responses were recorded from 165 cingulate neurons in anesthetized rats after electrical stimulation of the medial dorsal thalamus and vicinity. Forty-four of these cells (27%) showed an excitatory response to thalamic stimulation. In a further 40 cells that showed no baseline excitation, iontophoresis of the GABA(A) antagonist bicuculline methiodide revealed excitatory responses. The GABA(B) antagonist CGP-35348 attenuated longer-latency inhibition in 5 of 10 cells. In 23 of 49 (47%) of the above cells, AMPA antagonist iontophoresis (either CNQX or DNQX) selectively decreased the excitatory response to thalamic stimulation. The NMDA antagonist 3[(R)-2-carboxypiperazin-4-yl]-propyl-1-phosphonic acid had no such effect. These data suggest that the thalamic projection to anterior cingulate cortex is glutamatergic, acting principally via AMPA receptors, and that the response of cingulate neurons to thalamic stimulation is regulated by GABA acting at both GABA(A) and GABA(B) receptors.
引用
收藏
页码:477 / 484
页数:8
相关论文
共 37 条
[1]  
AGGLETON JP, 1983, EXP BRAIN RES, V52, P199
[2]   FELINE SUBTHALAMIC NUCLEUS NEURONS CONTAIN GLUTAMATE-LIKE BUT NOT GABA-LIKE OR GLYCINE-LIKE IMMUNOREACTIVITY [J].
ALBIN, RL ;
ALDRIDGE, JW ;
YOUNG, AB ;
GILMAN, S .
BRAIN RESEARCH, 1989, 491 (01) :185-188
[3]   AUTORADIOGRAPHIC EXAMINATION OF CORTICO-CORTICAL AND SUB-CORTICAL PROJECTIONS OF THE MEDIODORSAL-PROJECTION (PREFRONTAL) CORTEX IN THE RAT [J].
BECKSTEAD, RM .
JOURNAL OF COMPARATIVE NEUROLOGY, 1979, 184 (01) :43-62
[4]   SUB-CORTICAL INFLUENCES UPON PREFRONTAL CORTEX OF THE CAT [J].
CANEDO, A .
BRAIN RESEARCH, 1982, 232 (02) :449-454
[5]   SCHIZOPHRENIA - A SUBCORTICAL NEUROTRANSMITTER IMBALANCE SYNDROME [J].
CARLSSON, M ;
CARLSSON, A .
SCHIZOPHRENIA BULLETIN, 1990, 16 (03) :425-432
[6]  
CUENOD M, 1982, CYTOCHEMICAL METHODS, P17
[7]  
DOMESICK VB, 1973, BRAIN BEHAV EVOLUT, V6, P457
[8]   UNUSUAL FEATURES OF GABA RESPONSES IN LAYERS-IV-V NEURONS OF NEOCORTEX [J].
ELBEHEIRY, H ;
PUIL, E .
NEUROSCIENCE LETTERS, 1990, 119 (01) :83-85
[9]   INHIBITORY INFLUENCE OF THE MESOCORTICAL DOPAMINERGIC SYSTEM ON SPONTANEOUS ACTIVITY OR EXCITATORY RESPONSE INDUCED FROM THE THALAMIC MEDIODORSAL NUCLEUS IN THE RAT MEDIAL PREFRONTAL CORTEX [J].
FERRON, A ;
THIERRY, AM ;
LEDOUARIN, C ;
GLOWINSKI, J .
BRAIN RESEARCH, 1984, 302 (02) :257-265
[10]   THALAMIC AFFERENTS OF THE RAT INFRALIMBIC AND LATERAL AGRANULAR CORTICES [J].
FREEDMAN, LJ ;
CASSELL, MD .
BRAIN RESEARCH BULLETIN, 1991, 26 (06) :957-964