SERUM LEVELS OF INSULIN-LIKE GROWTH-FACTOR-1 IN SUBJECTS WITH OSTEOARTHRITIS OF THE KNEE - DATA FROM THE BALTIMORE LONGITUDINAL-STUDY OF AGING

被引：54

作者：

HOCHBERG, MC

LETHBRIDGECEJKU, M

SCOTT, WW

REICHLE, R

PLATO, CC

TOBIN, JD

机构：

[1] JOHNS HOPKINS UNIV,SCH MED,BALTIMORE,MD

[2] NIA,GERONTOL RES CTR,BALTIMORE,MD 21224

来源：

ARTHRITIS AND RHEUMATISM | 1994年 / 37卷 / 08期

关键词：

D O I：

10.1002/art.1780370811

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective. To examine the relationship between serum levels of insulin-like growth factor 1 (IGF-1) and osteoarthritis (OA) of the knee. Methods. Serum IGF-1 levels were compared in 162 male and 101 female subjects age greater than or equal to 20 stratified by presence of radiographic changes of OA of the knee. Results. Mean serum IGF-1 levels were significantly lower in subjects with knee OA; however, after adjustment for age-related changes in IGF-1 levels, these differences were no longer significant. Conclusion. These data fail to support the hypothesis that serum IGF-1 levels are reduced in subjects with OA of the knee independent of the known age-related changes in these levels.

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页码：1177 / 1180

页数：4

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