INTRACELLULAR TRANSLOCATION OF ENDOTHELIAL NITRIC-OXIDE SYNTHASE BY LYSOPHOSPHATIDYLCHOLINE

被引：5

作者：

DUDEK, R ^{[1
]}

WILDHIRT, S ^{[1
]}

SUZUKI, H ^{[1
]}

WINDER, S ^{[1
]}

BING, RJ ^{[1
]}

机构：

[1] HUNTINGTON MED RES INST,INST EXPTL CARDIOL,PASADENA,CA 91101

来源：

PHARMACOLOGY | 1995年 / 50卷 / 04期

关键词：

NITRIC OXIDE; NITRIC OXIDE SYNTHASE; ENZYME TRANSLOCATION; LYSOPHOSPHATIDYLCHOLINE; L-ARGININE; L-CITRULLINE;

D O I：

10.1159/000139290

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The amphiphile lysophosphatidylcholine (LPC) modulates the activity of membrane-associated enzymes such as phospholipase A(2), adenylate and guanylate cyclases and ATPase. LPC also relaxes vascular smooth muscle through production of nitric oxide. On the basis of reports that bradykinin translocates nitric oxide synthase (NOS) from the membrane to the cytosol, we investigated whether a similar translocation occurs with LPC. It was found that LPC translocated NOS from the membrane to the cytosolic fraction. Total NOS activity remained at the control level.

引用

页码：257 / 260

页数：4

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