INFRARED SPECTROSCOPIC CHARACTERIZATION OF MULTIPLE-SCLEROSIS PLAQUES IN THE HUMAN CENTRAL-NERVOUS-SYSTEM

被引:62
作者
CHOO, LP
JACKSON, M
HALLIDAY, WC
MANTSCH, HH
机构
[1] NATL RES COUNCIL CANADA,INST BIODIAGNOST,435 ELLICE AVE,WINNIPEG R3B 1Y6,MB,CANADA
[2] UNIV MANITOBA,HLTH SCI CTR,FAC MED,DEPT PATHOL,VINNIPEG R3A 1R9,MB,CANADA
关键词
INFRARED SPECTROSCOPY; MULTIPLE SCLEROSIS; MULTIPLE SCLEROSIS PLAQUE; CENTRAL NERVOUS SYSTEM; (HUMAN);
D O I
10.1016/0925-4439(93)90078-F
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Fourier transform infrared spectroscopy has been used for the characterisation of white matter, grey matter and multiple sclerosis plaques from human central nervous system tissue. We demonstrate significant differences in the infrared spectra of the three types of tissue, which show that an infrared spectroscopic discrimination of multiple sclerosis plaques from healthy brain tissue is possible in principle. The spectral changes reveal pronounced lipid loss in plaques, consistent with the demyelinating nature of the disease. The chronic plaques studied here can also be distinguished from other non-myelinated areas of the brain, based on differences in water content.
引用
收藏
页码:333 / 337
页数:5
相关论文
共 11 条
[1]   POLYMORPHIC PHASE-BEHAVIOR OF PHOSPHOLIPID-MEMBRANES STUDIED BY INFRARED-SPECTROSCOPY [J].
CASAL, HL ;
MANTSCH, HH .
BIOCHIMICA ET BIOPHYSICA ACTA, 1984, 779 (04) :381-401
[2]   THE CELLULAR AND MOLECULAR EVENTS OF CENTRAL-NERVOUS-SYSTEM REMYELINATION [J].
DUBOISDALCQ, M ;
ARMSTRONG, R .
BIOESSAYS, 1990, 12 (12) :569-576
[3]  
HESTER RE, 1991, SPECTROSCOPY BIOL MO
[4]  
JACKSON M, 1993, SPECTROCHIM ACTA REV, V15, P53
[5]   FOURIER SELF-DECONVOLUTION - A METHOD FOR RESOLVING INTRINSICALLY OVERLAPPED BANDS [J].
KAUPPINEN, JK ;
MOFFATT, DJ ;
MANTSCH, HH ;
CAMERON, DG .
APPLIED SPECTROSCOPY, 1981, 35 (03) :271-276
[6]  
MIYAZAWA T, 1967, POLY ALPHA AMINO ACI, P69
[7]  
Norton W.T., 1984, MYELIN, P147
[8]  
NORTON WT, 1984, MYELIN, P369
[9]   VIBRATIONAL ANALYSIS OF THE N-PARAFFINS .1. ASSIGNMENTS OF INFRARED BANDS IN THE SPECTRA OF C3H8 THROUGH N-C19H40 [J].
SNYDER, RG ;
SCHACHTSCHNEIDER, JH .
SPECTROCHIMICA ACTA, 1963, 19 (01) :85-116
[10]   PROTEIN-STRUCTURE BY FOURIER-TRANSFORM INFRARED-SPECTROSCOPY - 2ND DERIVATIVE SPECTRA [J].
SUSI, H ;
BYLER, DM .
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1983, 115 (01) :391-397