NEW CYCLOHEXYL-BASED CHIRAL AUXILIARIES - ENANTIOSELECTIVE SYNTHESIS OF ALPHA-HYDROXY ACIDS

被引：25

作者：

BASAVAIAH, D

KRISHNA, PR

机构：

[1] School of Chemistry, University of Hyderabad, Hyderabad

来源：

TETRAHEDRON | 1995年 / 51卷 / 44期

关键词：

D O I：

10.1016/0040-4020(95)00771-Y

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(1R, 2R)-2-(4-tert-Butylphenoxy) cyclohexan-1-ol (5) and (1R, 2R)-2-(4-phenylphenoxy) cyclohexan-1-ol (6) have been used for the first time as chiral auxiliaries. Addition of alkylzinc chlorides to the corresponding glyoxylates 5a, 6a, after hydrolysis, provided (R)-alpha-hydroxy acids in high optical purities.

引用

页码：12169 / 12178

页数：10

共 16 条

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