ANTIINFLAMMATORY ACTIVITY OF AMYLIN AND CGRP IN DIFFERENT EXPERIMENTAL-MODELS OF INFLAMMATION

被引：29

作者：

CLEMENTI, G ^{[1
]}

CARUSO, A ^{[1
]}

CUTULI, VMC ^{[1
]}

PRATO, A ^{[1
]}

DEBERNARDIS, E ^{[1
]}

FIORE, CE ^{[1
]}

AMICOROXAS, M ^{[1
]}

机构：

[1] UNIV CATANIA, SCH MED, DEPT MED PATHOL 1, I-95125 CATANIA, ITALY

来源：

LIFE SCIENCES | 1995年 / 57卷 / 14期

关键词：

CGRP; INFLAMMATION; VASCULAR PERMEABILITY;

D O I：

10.1016/0024-3205(95)02100-W

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The anti-inflammatory activity of amylin was studied in different models of inflammation, and compared to that of CGRP. Both peptides were active against mouse ear oedema induced by croton oil and acetic acid-induced peritonitis in the rat. CGRP was more potent than amylin in both models. Pretreatment with CORP 8-37 fragment blocked the anti-inflammatory activity of both peptides in croton oil ear oedema. No anti-inflammatory activity was evidenced against serotonin-induced rat paw oedema and plasma protein extravasation induced by dextran in rat skin. Our results suggest that amylin exerts anti-inflammatory activity only in inflammatory models characterized by a vascular component. This effect appears to be mediated by the involvement of CGRP receptors.

引用

页码：PL193 / PL197

页数：5

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