NORETHANDROLONE IN CYSTIC FIBROSIS OF PANCREAS

Twenty-eight patients with advanced changes secondary to cystic fibrosis were given thesynthetic anabolic steroid, norethandrolone. Subjective improvement was noted in most patients; however, significant improvement in nutrition was noted only in the preadolescent females. Improvement in pulmonary function was also noted only in that group. It is hypothesized that the more severe course of the female with this illness may relate either to a possible low endogenous androgen secretion or a possible effect of gonadotropins on mucous viscosity that is blocked by this anabolic agent. © 1969 The C. V. Mosby Company.