EFFECT OF SECRETIN AND PANCREOZYMIN ON PANCREATIC BLOOD FLOW IN CONSCIOUS AND ANESTHETIZED DOG

Pancreatic blood flow was studied in dogs by measuring local hydrogen gas clearance. External pancreatic secretion was collected by cannulation for volume measurements. In 16 expts. (15 dogs), recordings were obtained in pentobarbital (Nembutal) anesthesia. The mean value of 115 observations was 42.8 (S.E. 4.3) ml/min. 100 g pancreas. In 3 dogs, measurements were made in the awake, fasted state by means of chronically implanted electrodes, which proved effective for about two weeks. Mean of 33 observations was 76 ml/min. 100 g. The correlation between pancreatic blood flow and external secretion was studied by means of secretin (Boots, Jorpes) and pancreozymin (Boots). A variable response occurred, which proved to be time‐dependent and not correlated to the state of secretion or stimulation. An acute rise in blood flow was seen when hormone administration was started or increased. This effect was immediate but transient; blood flow returned to pre‐stimulatory level after 20 min, whereas the external secretion continued unchanged. No effect was noticed on gastric hydrogen clearance recorded in 4 of the dogs, indicating an organ specificity of the hormonal influence. © 1969 Scandinavian Physiological Society