INHIBITION OF RAT MAST-CELL DEGRANULATION AND HISTAMINE-RELEASE BY HISTAMINE RAT GAMMAGLOBULIN CONJUGATE

被引：12

作者：

ISHIKAWA, T

SHIMADA, T

KESSOKU, N

KIYOI, M

机构：

[1] NIPPON ZOKI PHARMACEUT CO,RES LAB,OSAKA,JAPAN

[2] CHIBA UNIV,SCH MED,DEPT OTOLARYNGOL,DIV ALLERGY & CLIN IMMUNOL,CHIBA 280,JAPAN

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY | 1979年 / 59卷 / 04期

关键词：

D O I：

10.1159/000232287

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Histamine-rat γ-globulin conjugate inhibited degranulation and histamine release of rat peritoneal mast cells to a greater extent than the rat globulin or histamine alone. Since mast cells contain histamine receptors, it may be assumed that the histamine bound to the γ-globulin combines with the rat mast cell histamine receptor and inhibits the degranulation and histamine release by a feedback mechanism.

引用

页码：403 / 407

页数：5

共 10 条

[1]

AUSTEN KF, 1971, IMMUNOLOGICAL DISEAS, P332

[2]

BOURNE HR, 1972, J IMMUNOL, V108, P695

[3]

JOHNSON AR, 1969, FED PROC, V28, P1716

[4]

KOROTZER JL, 1971, IMMUNOLOGY, V20, P545

[5]

KRUGER G, 1976, INT ARCH ALLER A IMM, V51, P608

[6] HISTAMINE RELEASE IN VITRO - INHIBITION BY CATECHOLAMINES AND METHYLXANTHINES [J].

LICHTENS.LM ;

MARGOLIS, S .

SCIENCE, 1968, 161 (3844) :902-&

[7]

LICHTENSTEIN LM, 1971, BIOCH ACUTE ALLERGIC, P161

[8] DETECTION OF IGE MEDIATED IMMEDIATE HYPERSENSITIVITY REACTIONS IN SERA OF RAGWEED SENSITIVE INDIVIDUALS USING RAT MAST CELLS [J].

PERELMUTTER, L ;

LIAKOPOULOU, A .

INTERNATIONAL ARCHIVES OF ALLERGY AND APPLIED IMMUNOLOGY, 1971, 40 (4-5) :481-+

[9]

SHORE PA, 1959, J PHARMACOL EXP THER, V127, P182

[10]

UVNAS B, 1971, BIOCH ACUTE ALLERGIC, P175

← 1 →