INFLUENCE OF NUCLEOTIDE-SEQUENCE ON DA.DT-SPECIFIC BINDING OF NETROPSIN TO DOUBLE STRANDED DNA

被引：59

作者：

ZIMMER, C

MARCK, C

SCHNEIDER, C

GUSCHLBAUER, W

机构：

[1] CENS,DEPT BIOL,SERV BIOPHYS B,F-91190 GIF SUR YVETTE,FRANCE

[2] CENS,DEPT BIOL,SERV BIOCHIM C,F-91190 GIF SUR YVETTE,FRANCE

来源：

NUCLEIC ACIDS RESEARCH | 1979年 / 6卷 / 08期

关键词：

D O I：

10.1093/nar/6.8.2831

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Using CD measurements the complex formation of Netropsin (Nt) with poly(dA-dC)·poly(dT-dG) and its stability against high salt concentrations is compared with that of poly(dA)·poly(dT) and poly(dA-dT)·poly(dT-dA). It is experimentally shown that the insertion of a dG·dC pair in dA·dT sequences strongly reduces the specific interaction of Nt with DNA duplexes. The specificity of the interaction is strongly increased by two or more consecutive thymine residues as present in thymine isostichs of double stranded DNA's. © 1979 Information Retrieval Limited.

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页码：2831 / 2837

页数：7

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