MOOD CHANGES AND ON-OFF PHENOMENA IN PARKINSONS-DISEASE

被引：114

作者：

MENZA, MA

SAGE, J

MARSHALL, E

CODY, R

DUVOISIN, R

机构：

[1] Departments of Psychiatry and Neurology, Robert Wood Johnson Medical School, New Brunswick, New Jersey

来源：

MOVEMENT DISORDERS | 1990年 / 5卷 / 02期

关键词：

Affect; Depression; Dyskinesia; Mood; On‐off; Parkinson's disease;

D O I：

10.1002/mds.870050210

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Ten patients with idiopathic Parkinson's disease and motor fluctuations were rated for mood changes during discrete “off,” “on,” and “on with dyskinesia” periods. The Profile of Mood States and visual analogue scales were used. Significant changes in mood and anxiety were found to parallel changes in motor fluctuations. One patient rated his moods as consistently improving from the “off” state to the “on” state and finally to the “on with dyskinesia” state, a finding that is consistent with concomitant central dopaminergic changes. All other patients showed moods that improved significantly from the “off” state to the “on” state but then worsened significantly in the “on with dyskinesia” state, a finding that is consistent with the fact that patients feel worse when impaired by dyskinesias. It is suggested that these results argue for multiple etiologies of depression in Parkinson's disease. The literature on dopamine and depression in Parkinson's disease is briefly reviewed and the opportunity provided by “on‐off” phenomena to study the effect of dopamine on mood changes is discussed. Copyright © 1990 Movement Disorder Society

引用

页码：148 / 151

页数：4

共 21 条

[1]

Rinne UK, Problems associated with long‐term levodopa treatment of Parkinson's disease, Acta Neurol Scand, 68, pp. 19-26, (1983)

[2]

Lorr M, McNair D, Fisher S., Evidence for bipolar mood states, J Pers Assess, 46, pp. 432-436, (1982)

[3]

Bond A, Lader M., The use of analogue scales in rating subjective feeling, British Journal of Medical Psychology, 47, pp. 211-218, (1974)

[4]

Gotham AM, Brown RG, Marsden CD, Depression in Parkinson's disease: a quantitative and qualitative analysis, J Neurol Neurosurg Psychiatry, 49, pp. 381-389, (1986)

[5]

Robins AH, Depression in patients with parkinsonism, Br J Psychiatry, 128, pp. 141-145, (1976)

[6]

Mayeux R, Stern Y, Cote L, Williams J., Altered serotonin metabolism in depressed patients with Parkinson's disease, Neurology, 34, pp. 642-646, (1984)

[7]

Taylor AE, Saint-Cyr JA, Lang AE, Et al., Depression in Parkinson's disease: a critical re‐evaluation, Brain, 109, pp. 279-292, (1986)

[8]

Willner P., Dopamine and depression: a review of recent evidence, Brain Res Rev, 287, (1983)

[9]

Maas JW, Biogenic amines and depression, Arch Gen Psychiatry, 32, pp. 1357-1364, (1975)

[10]

Bunney WE, Janowsky DS, Goodwin FK, Effect of L‐dopa on depression, Lancet, 1, (1969)

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