THE GABAERGIC NIGROCOLLICULAR PATHWAY IS NOT INVOLVED IN THE INHIBITORY CONTROL OF AUDIOGENIC-SEIZURES IN THE RAT

被引：22

作者：

DEPAULIS, A ^{[1
]}

MARESCAUX, C ^{[1
]}

LIU, Z ^{[1
]}

VERGNES, M ^{[1
]}

机构：

[1] HOP CIVIL STRASBOURG,NEUROL CLIN,STRASBOURG,FRANCE

来源：

NEUROSCIENCE LETTERS | 1990年 / 111卷 / 03期

关键词：

Audiogenic seizure; Epilepsy; Microinjection; Rat; Substantia nigra; Superior colliculus; γ-Aminobutyric acid;

D O I：

10.1016/0304-3940(90)90273-C

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Involvement of the GABAergic nigro-collicular pathway in the control of audiogenic seizures was examined in genetically sensitive rats by studying the effects of bilateral injections into the substantia nigra of muscimol, a γ-Aminobutyric acid (GABA) agonist, and those of bilateral injections into the superior colliculus of picrotoxin, a GABA antagonist, and of muscimol. Microinjections of muscimol (20-80 ng/side) into the substantia nigra and microinjections into the superior colliculus of picrotoxin (20 and 40 ng/side) both failed to suppress audiogenic seizures. Following injections into the superior colliculus, audiogenic seizures were in fact facilitated by picrotoxin and suppressed by muscimol. These results suggest that the nigro-collicular GABAergic pathway is not involved in the inhibitory control over audiogenic seizures. Conversely, a different GABAergic mechanisms may be involved in the superior colliculus in the control of this form of epilepsy. © 1990.

引用

页码：269 / 274

页数：6

共 21 条

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