EXPRESSION OF BETA-NERVE GROWTH-FACTOR RECEPTOR MESSENGER-RNA IN SERTOLI CELLS DOWNREGULATED BY TESTOSTERONE

被引：150

作者：

PERSSON, H

AYERLELIEVRE, C

SODER, O

VILLAR, MJ

METSIS, M

OLSON, L

RITZEN, M

HOKFELT, T

机构：

[1] KAROLINSKA INST,DEPT HISTOL & NEUROBIOL,S-10401 STOCKHOLM 60,SWEDEN

[2] KAROLINSKA HOSP,PEDIAT ENDOCRINOL UNIT,S-10401 STOCKHOLM 60,SWEDEN

来源：

SCIENCE | 1990年 / 247卷 / 4943期

关键词：

D O I：

10.1126/science.2154035

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nerve growth factor (NGF) is synthesized in male germ cells. The NGF receptor (NGFR) mRNA was found in the Sertoli cells of rat testis. Hypophysectomy increased both NGFR mRNA in testis and the number of NGFR hybridizing cells in seminiferous tubules. This was suppressed by treatment with chorionic gonadotropin or testosterone, but not with follicle-stimulating hormone. The NGFR mRNA also increased after destruction of Leydig cells or blocking of the androgen receptor. This suggests that NGF produced by male germ cells regulates testicular function in an androgen-modulated fashion by mediating an interaction germ and Sertoli cells.

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页码：704 / 707

页数：4

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