AMPHOTERICIN-B O-METHYL OXIME - SYNTHESIS AND BIOLOGICAL PROPERTIES

被引：6

作者：

CZERWINSKI, A

KONIG, WA

SOWINSKI, P

FALKOWSKI, L

MAZERSKI, J

BOROWSKI, E

机构：

[1] UNIV HAMBURG,INST ORGAN CHEM,W-2000 HAMBURG 13,GERMANY

[2] POLISH ACAD SCI,INST OCEANOL,PL-81967 SOPOT,POLAND

来源：

JOURNAL OF ANTIBIOTICS | 1990年 / 43卷 / 09期

关键词：

D O I：

10.7164/antibiotics.43.1098

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Synthesis and biological properties of amphotericin B O-methyl oxime are described. The presence of an intact hemiketal ring in the antibiotic molecule appeared to be essential for its biological activity. © 1990, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.

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页码：1098 / 1100

页数：3

相关论文

共 13 条

[1] COMPARATIVE CONFORMATIONAL-ANALYSIS OF CHOLESTEROL AND ERGOSTEROL BY MOLECULAR MECHANICS [J].

BAGINSKI, M ;

TEMPCZYK, A ;

BOROWSKI, E .

EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, 1989, 17 (03) :159-166

[2]

BOROWSKI E, 1971, TETRAHEDRON LETT, P1987

[3] THE PROTON MAGNETIC-RESONANCE SPECTRUM OF AMPHOTERICIN-B [J].

BROWN, JM ;

SIDEBOTTOM, PJ .

TETRAHEDRON, 1981, 37 (07) :1421-1428

[4] QUANTITATIVE STRUCTURE ACTIVITY RELATIONSHIPS IN AMPHOTERICIN-B DERIVATIVES [J].

CHERON, M ;

CYBULSKA, B ;

MAZERSKI, J ;

GRZYBOWSKA, J ;

CZERWINSKI, A ;

BOROWSKI, E .

BIOCHEMICAL PHARMACOLOGY, 1988, 37 (05) :827-836

[5] AMIDES OF POLYENE MACROLIDE AUREOFACIN SYNTHESIS AND BIOLOGICAL PROPERTIES [J].

CZERWINSKI, A ;

KONIG, WA ;

SOWINSKI, P ;

BOROWSKI, E .

JOURNAL OF ANTIBIOTICS, 1987, 40 (07) :1023-1027

[6] THE STRUCTURE OF MEPARTRICIN-A AND MEPARTRICIN-B [J].

GOLIK, J ;

ZIELINSKI, J ;

BOROWSKI, E .

JOURNAL OF ANTIBIOTICS, 1980, 33 (08) :904-906

[7] THE ROLE OF THE CARBOXYL AND AMINO-GROUPS OF POLYENE MACROLIDES IN THEIR INTERACTIONS WITH STEROLS AND THEIR SELECTIVE TOXICITY - A P-31-NMR STUDY [J].

HERVE, M ;

DEBOUZY, JC ;

BOROWSKI, E ;

CYBULSKA, B ;

GARYBOBO, CM .

BIOCHIMICA ET BIOPHYSICA ACTA, 1989, 980 (03) :261-272

[8]

KOMORI T, 1989, TETRAHEDRON LETT, V30, P3813

[9]

MECHLINSKI W, 1970, TETRAHEDRON LETT, P3873

[10] POLYENE ANTIBIOTICS .7. C-13 NUCLEAR MAGNETIC-RESONANCE EVIDENCE FOR CYCLIC HEMIKETALS IN POLYENE ANTIBIOTICS AMPHOTERICIN-B, NYSTATIN-A1, TETRIN-A, TETRIN-B, LUCENSOMYCIN, AND PIMARICIN [J].

PANDEY, RC ;

RINEHART, KL .

JOURNAL OF ANTIBIOTICS, 1976, 29 (10) :1035-1042