EFFECTS OF CONCURRENT NICOTINIC ANTAGONIST AND PCPA TREATMENTS ON SPATIAL AND PASSIVE-AVOIDANCE LEARNING

被引：30

作者：

RIEKKINEN, P

RIEKKINEN, M

SIRVIO, J

RIEKKINEN, P

机构：

[1] Department of Neurology, University of Kuopio, Kuopio

来源：

BRAIN RESEARCH | 1992年 / 575卷 / 02期

关键词：

NICOTINIC CHOLINERGIC RECEPTOR; MECAMYLAMINE; SEROTONIN; PARA-CHLOROPHENYLALANINE; LEARNING PERFORMANCE; ALZHEIMERS DISEASE;

D O I：

10.1016/0006-8993(92)90086-O

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study investigates the effects of concurrent manipulations of nicotinic cholinergic receptors (mecamylamine 10 mg/kg, i.p.) and serotonin neurons (PCPA, 400 mg on each of 4 days) on spatial navigation (water maze, WM) and passive avoidance (PA) performance. PCPA treatment had no effect on WM navigation or PA performance of intact rats, but greatly aggravated mecamylamine induced performance deficit. Either single or combined treatments with hexamethonium (5.0 mg/kg, s.c.) and PCPA had no effect on WM or PA performance. These findings may suggest that nicotinic cholinergic receptors are are also importantly involved in the cholinergic-serotonergic regulation of cognitive functioning.

引用

页码：247 / 250

页数：4

共 25 条

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