THE EFFECT OF CALCIUM-CHANNEL MODULATORS ON BLOOD-PRESSURE AND PRESSOR-RESPONSES TO NORADRENALINE IN THE GUINEA-PIG

被引：10

作者：

BOND, A ^{[1
]}

BOOT, JR ^{[1
]}

机构：

[1] LILLY RES CTR LTD,ERL WOOD MANOR,WINDLESHAM GU20 6PH,SURREY,ENGLAND

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 218卷 / 01期

关键词：

CA2+ CHANNEL ANTAGONISTS; CARDIOVASCULAR EFFECTS; OMEGA-CONOTOXIN GVIA; (GUINEA-PIG);

D O I：

10.1016/0014-2999(92)90163-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Selective L-type voltage-operated calcium channel (VOCC) antagonists nicardipine, diltiazem and verapamil all produced pronounced falls in mean arterial blood pressure (MAP) in the anaesthetized artificially ventilated guinea-pig. This fall in MAP was associated with a significant reduction of the pressor response induced by i.v. noradrenaline. Omega-conotoxin GVIA (CgTx) a preferential N-type VOCC antagonist produced a significant time-dependent fall in MAP. similar in magnitude to the L-type VOCC antagonist, but did not affect the noradrenaline-induced pressor responses.

引用

页码：179 / 181

页数：3

共 6 条

[1]

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