DEPLETION OF TRYPTOPHAN IS NOT INVOLVED IN EXPRESSION OF TRYPTOPHANYL-TRANSFER RNA-SYNTHETASE MEDIATED BY INTERFERON

被引：17

作者：

FLOHR, T ^{[1
]}

BANGE, FC ^{[1
]}

VONEUCH, A ^{[1
]}

KIEKENBECK, M ^{[1
]}

BOTTGER, EC ^{[1
]}

机构：

[1] MED SCH HANNOVER,INST MED MICROBIOL,KONSTANTY GUTSCHOW STR 8,W-3000 HANNOVER 61,GERMANY

来源：

INFECTION AND IMMUNITY | 1992年 / 60卷 / 10期

关键词：

D O I：

10.1128/IAI.60.10.4418-4421.1992

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Gamma interferon (IFN-gamma) affects tryptophan metabolism by mediating the expression of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA synthetase. In the present study, we investigated the role of indoleamine 2,3-dioxygenase-mediated tryptophan depletion in the induction of tryptophanyl-tRNA synthetase by IFN-gamma. The addition of excess tryptophan to the culture medium did not affect the induction of tryptophanyl-tRNA synthetase by IFN-gamma, indicating that tryptophan degradation is not directly involved in the IFN-gamma-mediated expression of tryptophanyl-tRNA synthetase.

引用

页码：4418 / 4421

页数：4

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