METHODS FOR THE SYNTHESIS OF L-LEUCINE SELECTIVELY LABELED WITH C-13 OR DEUTERIUM IN EITHER DIASTEREOTOPIC METHYL-GROUP

被引：18

作者：

KELLY, NM

REID, RG

WILLIS, CL

WINTON, PL

机构：

[1] UNIV BRISTOL, SCH CHEM, BRISTOL BS8 1TS, AVON, ENGLAND

[2] AMERSHAM INT PLC, CARDIFF CF4 7YT, S GLAM, WALES

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 45期

关键词：

D O I：

10.1016/0040-4039(95)01738-4

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A versatile approach is described for the enantioselective synthesis of isotopically labelled L-leucine involving the preparation of 2-oxo-4-methylpentanoic acid labelled selectively with carbon-13 or deuterium in either the pro-R or pro-S methyl group followed by a reductive amination of the ketone catalysed by leucine dehydrogenase. This strategy is applied to the total synthesis of (2S,4R)-[5,5,5-D-3]-leucine using CD3I as the source of deuterium.

引用

页码：8315 / 8318

页数：4

共 9 条

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