THE 35-PERCENT CO2 CHALLENGE IN PANIC DISORDER - OPTIMIZATION BY RECEIVER OPERATING CHARACTERISTIC (ROC) ANALYSIS

被引:84
作者
BATTAGLIA, M [1 ]
PERNA, G [1 ]
机构
[1] UNIV MILAN, HOSP SAN RAFFAELE,SCH MED,IRCCS, DEPT NEUROPSYCHIAT SCI, I-20127 MILAN, ITALY
关键词
D O I
10.1016/0022-3956(94)00045-S
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
To test the power of the 35% CO2 test as a challenge for panic disorder (PD), and to set an ideal threshold of discrimination between patients and controls, we analysed by receiver operating characteristic (ROC) analysis the responses of 91 out-patients with PD and 46 controls who inhaled a 35% CO2/65% O-2 gas mixture. ROC analysis confirmed that the CO2 challenge discriminates well between PD patients and controls, with 86% probability to classify them correctly on the basis of subjective anxiety after the test. A relatively modest increment in subjective anxiety (i.e. an absolute increment of 20 units, or a relative increment of 26% of subjective anxiety) proved to be the ideal threshold to separate the two groups of our sample.
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页码:111 / 119
页数:9
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