INTERPLAY BETWEEN NUCLEOSOMES AND TRANSCRIPTION FACTORS AT THE YEAST PHO5 PROMOTER

被引：18

作者：

SVAREN, J ^{[1
]}

HORZ, W ^{[1
]}

机构：

[1] UNIV MUNICH,INST PHYSIOL CHEM,D-80336 MUNICH,GERMANY

来源：

SEMINARS IN CELL BIOLOGY | 1995年 / 6卷 / 04期

基金：

美国国家科学基金会;

关键词：

ACTIVE CHROMATIN; NUCLEOSOME DISRUPTION; IN-VIVO FOOTPRINT; YEAST; PHO4;

D O I：

10.1006/scel.1995.0025

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In this review, we summarize experiments which have used the yeast PHO5 gene to determine the functional consequences of nucleosome structure in the promoter region. In the PHO5 system, nucleosomes participate in promoter repression by interfering with factor binding. Therefore, disruption of nucleosome structure is likely a prerequisite for promoter activation. There still remain several important questions regarding the assembly and disassembly of chromatin repression. Recent experiments have shown that the PHO5 chromatin transition is replication and transcription independent. Nucleosome disruption does, however, depend upon binding of a transactivator, Pho4, to the PHO5 promoter. Moreover, the activation domain of Pho4 appears to play a critical rob in chromatin disruption.

引用

页码：177 / 183

页数：7

共 52 条

[1] REMOVAL OF POSITIONED NUCLEOSOMES FROM THE YEAST PHO5 PROMOTER UPON PHO5 INDUCTION RELEASES ADDITIONAL UPSTREAM ACTIVATING DNA ELEMENTS [J].