EFFECTS OF CONTINUOUS INTRAMESENTERIC INFUSION OF GLUCOSE AND AMINO-ACIDS ON FOOD-INTAKE IN RATS

Prolonged infusions of various fluids at a rate of 21 ml/23.5 hr through the mesenteric vein and the vena were performed on rats and effects on ad lib food intake were determined. Results indicate that continuous intramesenteric infusion of 5-10% glucose solutions or a 5% Aminofusin L solution suppresses food intake. No effects were observed when solutions were infused via the caval vein. A 10% solution of 3-O-methyl-d-glucose did not affect food intake when introduced by either route. These data support directly the presence of glucose and amino acid receptive mechanisms in the portohepatic system involved in the control of food intake. © 1979.