EXPERIMENTAL TOXICITY AND METABOLISM OF 1,2,6-HEXANETRIOL

The toxicity of 1,2,6-hexanetriol was determined in rats, rabbits, and dogs. In rats the LD50 values are 16 ml/kg orally, 10 g/kg intraperitoneally, and 5.6 ml/kg intravenously. Inunctions of 2 ml/kg 30 times within 6 weeks produced no effect in rabbits. Fed in the diet of rats for 2 years, a 5% concentration reduced growth, increased relative kidney weight during the first year, and resulted in some cloudy swelling in liver and pancreas, but 1% was without deleterious effect. In the diet of dogs for 2 years, 1% was without effect. In rats, 79% of a large dose was found in the urine within 24 hours, apparently unchanged and unconjugated. The triol is not converted to glycogen and stored in the liver. Approximately 0.1% of the dose appears in rat urine as oxalic acid. The triol is considerably more potent a diuretic than glycerin. Hexanetriol is not appreciably toxic to rats, rabbits, and dogs when given in either single or repeated doses by various routes. It is essentially unmetabolized by rats. © 1969.