INFLUENCE OF THE MAJOR HISTOCOMPATIBILITY COMPLEX (H-2) ON EXPERIMENTAL DIABETES IN MICE

被引：21

作者：

KROMANN, H

LERNMARK, A

VESTERGAARD, BF

EGEBERG, J

NERUP, J

机构：

[1] UNIV UMEA,DEPT HISTOL,S-90185 UMEA,SWEDEN

[2] UNIV COPENHAGEN,DEPT MED MICROBIOL,COPENHAGEN,DENMARK

[3] UNIV COPENHAGEN,ANAT DEPT B,COPENHAGEN,DENMARK

来源：

DIABETOLOGIA | 1979年 / 16卷 / 02期

关键词：

autoimmunity; Experimental diabetes mellitus; glucose intolerance; immune response genes; islet-cell-surface antibody; major histocompatibility locus; virus;

D O I：

10.1007/BF01225459

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Mice with different histocompatibility loci on an identical background genome (congenic resistant lines of mice) were used to study the possible influence of the histocompatibility complex on experimental diabetes. The major histocompatibility complex (H-2) was not found to influence the diabetogenic effect of encephalomyocarditis (EMC) virus. In contrast the glucose intolerance following heterologous and homologous immunization with pancreatic antigens appeared H-2 influenced. Antibodies against cell surface components on viable B-cells were present in serum from mice with glucose intolerance induced by homologous immunization. The results suggest that the susceptibility to experimental autoimmune diabetes in mice is influenced by the H-2 complex. © 1979 Springer-Verlag.

引用

页码：107 / 114

页数：8

共 40 条

[1] ISLET-CELL ANTIBODIES IN DIABETES-MELLITUS WITH AUTOIMMUNE POLY-ENDOCRINE DEFICIENCIES
BOTTAZZO, GF
FLORINCH.A
DONIACH, D
[J]. LANCET, 1974, 2 (7892) : 1279 - 1283
[2] BOUCHER DW, 1975, J INFECT DIS, V131, P462
[3] BUSCHARD K, 1976, ACTA PATH MICRO IM C, V84, P299
[4] DIABETES IN MICE AFTER COXSACKIE B4 VIRUS-INFECTION
COLEMAN, TJ
GAMBLE, DR
TAYLOR, KW
[J]. BRITISH MEDICAL JOURNAL, 1973, 3 (5870) : 25 - 27
[5] CRAIGHEAD JE, 1966, AM J PATHOL, V48, P333
[6] DIABETES MELLITUS - INDUCTION IN MICE BY ENCEPHALOMYOCARDITIS VIRUS
CRAIGHEAD, JE
MCLANE, MF
[J]. SCIENCE, 1968, 162 (3856) : 913 - +
[7] MORPHOLOGY OF EXPERIMENTAL, ORGAN-SPECIFIC INSULITIS OF MOUSE PANCREAS
EGEBERG, J
NERUP, J
ORTVEDANDERSEN, O
BENDIXEN, G
KROMANN, H
GUNNARSSON, R
HELLERSTROM, C
POULSEN, JE
[J]. ACTA ENDOCRINOLOGICA, 1976, 83 (01): : 133 - 150
[8] STRAIN DIFFERENCES IN AUTOIMMUNE-RESPONSE OF MICE TO ACETYLCHOLINE RECEPTORS
FUCHS, S
NEVO, D
TARRABHAZDAI, R
YAAR, I
[J]. NATURE, 1976, 263 (5575) : 329 - 330
[9] GENETIC-CONTROL OF SUSCEPTIBILITY TO EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN RATS
GASSER, DL
NEWLIN, CM
PALM, J
GONATAS, NK
[J]. SCIENCE, 1973, 181 (4102) : 872 - 873
[10] PATHOLOGIC ANATOMY OF PANCREAS IN JUVENILE DIABETES MELLITUS
GEPTS, W
[J]. DIABETES, 1965, 14 (10) : 619 - +

← 1 2 3 4 →