CALCULATIONS OF DRUG RELEASE RATES FROM CONTROLLED RELEASE DEVICES - SLAB

被引：52

作者：

HADGRAFT, J ^{[1
]}

机构：

[1] UNIV STRATHCLYDE,DEPT PHARMACEUT CHEM,GLASGOW G1 1XW,SCOTLAND

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1979年 / 2卷 / 3-4期

关键词：

D O I：

10.1016/0378-5173(79)90019-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Mathematical expressions have been derived to describe rates of drug release from controlled release devices. The devices have been limited to those of a non-degradable nature and which have the geometry of a plane sheet. Full solutions to Ficks' Laws of diffusion have been compared with the approximate solutions in general use. Multiphase layers have been considered and equations show the effect of slow interfacial transfer between these layers. © 1979.

引用

页码：177 / 194

页数：18

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