COUMARIN MERCAPTURIC ACID ISOLATED FROM RAT URINE INDICATES METABOLIC FORMATION OF COUMARIN 3,4-EPOXIDE

被引：30

作者：

HUWER, T

ALTMANN, HJ

GRUNOW, W

LENHARDT, S

PRZYBYLSKI, M

EISENBRAND, G

机构：

[1] UNIV KAISERSLAUTERN,FR LEBENSMITTELCHEM & UMWELTTOXIKOL,W-6750 KAISERSLAUTERN,GERMANY

[2] BUNDESGESUNDHEITSAMT,MAX VON PETTENKOFER INST,W-1000 BERLIN,GERMANY

[3] UNIV CONSTANCE,FAC CHEM,W-7750 CONSTANCE,GERMANY

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 1991年 / 4卷 / 05期

关键词：

D O I：

10.1021/tx00023a016

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A coumarin mercapturic acid, N-acetyl-S-(3-coumarinyl)cysteine, has been identified in the urine of coumarin-treated rats. [C-14]Coumarin was applied by gavage as a single dose to male Wistar rats (10-150 mg/kg body weight). Twenty-four-hour urine was collected, and the deproteinized concentrate was analyzed for radiolabeled metabolites by HPLC. The new mercapturic acid metabolite is supposed to result from oxidative biotransformation of coumarin to its 3,4-epoxide and subsequent coupling with glutathione.

引用

页码：586 / 590

页数：5

共 17 条

[1]

BAR F, 1967, MED ERNAHR, V8, P244

[2]

BOOTH AN, 1959, J BIOL CHEM, V234, P946

[3] CRITICAL-REVIEW OF THE TOXICOLOGY OF COUMARIN WITH SPECIAL REFERENCE TO INTERSPECIES DIFFERENCES IN METABOLISM AND HEPATOTOXIC RESPONSE AND THEIR SIGNIFICANCE TO MAN [J].