ISOLATION OF IGGT FROM HYPERIMMUNE HORSE ANTI-SNAKE VENOM SERUM - ITS PROTECTIVE ABILITY

被引：27

作者：

FERNANDES, I ^{[1
]}

TAKEHARA, HA ^{[1
]}

MOTA, I ^{[1
]}

机构：

[1] INST BUTANTAN,IMMUNOL RES & TRAINING CTR OTTO G BIER,AV VITAL BRAZIL 1500,BR-05504 SAO PAULO,BRAZIL

来源：

TOXICON | 1991年 / 29卷 / 11期

基金：

巴西圣保罗研究基金会;

关键词：

EQUINE;

D O I：

10.1016/0041-0101(91)90124-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hyperimmune horse anti-bothropic serum, used in serum therapy, was analyzed for its IgG(T) content and protective ability. IgG(T) was isolated through a combination of salt-mediated hydrophobic chromatography and protein A affinity chromatography. The chromatographic fractions obtained were analyzed with regard to their isotype content and protective ability. The results suggest that the protective ability of hyperimmune antivenom serum is located mainly in the IgG(T)subclass.

引用

页码：1373 / 1379

页数：7

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