MOVABLE LOBES AND FLEXIBLE LOOPS IN PROTEINS - STRUCTURAL DEFORMATIONS THAT CONTROL BIOCHEMICAL-ACTIVITY

被引：82

作者：

KEMPNER, ES

机构：

[1] Laboratory of Physical Biology National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, Bethesda

来源：

FEBS LETTERS | 1993年 / 326卷 / 1-3期

关键词：

ENZYME; REACTION RATE; STRUCTURE FUNCTION; DOMAIN;

D O I：

10.1016/0014-5793(93)81749-P

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two classes of protein whose structure is modified by small ligands are reviewed. Proteins of one group contain two massive domains joined by a flexible link; in response to small molecules, the two lobes approach and enclose the ligand. In the other, a short segment of amino acids moves as a flexible loop over the ligand which often is trapped in a non-aqueous environment. Biochemical reaction rates are altered dramatically by these movements.

引用

页码：4 / 10

页数：7

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