SEQUENTIAL MONITORING OF CLINICAL-TRIALS - THE ROLE OF INFORMATION AND BROWNIAN-MOTION

被引:90
作者
LAN, KKG [1 ]
ZUCKER, DM [1 ]
机构
[1] NHLBI, BIOSTAT RES BRANCH, BETHESDA, MD 20892 USA
关键词
D O I
10.1002/sim.4780120804
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Sequential monitoring has been a topic of major interest in clincal trials methodology over the past two decades. This paper presents a unified conceptual framework for sequential monitoring that covers a wide variety of monitoring procedures in a wide variety of clinical trial settings. The central elements of this framework consist of a suitable concept of statistical information and a scheme for using this concept as a basis for summarizing the accumulating results of a trial in a standardized form, through a stochastic process that can be shown to approximate classical Brownian motion. The ideas are developed in a simple step-by-step fashion and illustrated by several practical examples.
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页码:753 / 765
页数:13
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