MULTIPLE-DOSE PHARMACOKINETICS OF MOXISYLYTE AFTER ORAL-ADMINISTRATION TO HEALTHY-VOLUNTEERS

被引:6
作者
COSTA, P
BRESSOLLE, F
JARROUX, E
SARRAZIN, B
MOSSER, J
NAVRATIL, H
GALTIER, M
机构
[1] FAC PHARM MONTPELLIER,DEPT PHARMACOCINET,AV C FLAHAULT,F-34060 MONTPELLIER 1,FRANCE
[2] CHU G DOUMERGUE,SERV UROL ANDROL,NIMES,FRANCE
[3] LAB SARGET,DEPT RECH CLIN,MERIGNAC,FRANCE
[4] CHU CAREMEAU,PHARMACOCINET LAB,NIMES,FRANCE
关键词
D O I
10.1002/jps.2600820920
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
The pharmacokinetics of moxisylyte in plasma and urine was investigated after oral administration. Twelve subjects were treated orally, twice daily with 240 mg of the drug for 6 days; on day 7, the subjects received a last dose of 240 mg of moxisylyte. Moxisylyte was assayed in plasma and urine by a specific HPLC method with fluorimetric detection. Moxisylyte was absorbed rapidly and changed to its metabolites immediately after drug administration; unchanged moxisylyte was not found in plasma. Two metabolites were found in plasma and urine: conjugated desacetylmoxisylyte (DAM) and the conjugate of desmethylated DAM (MDAM). The pharmacokinetic parameters determined after the first oral administration were not modified on multiple dosing. The apparent elimination half-lives of conjugated DAM and MDAM were 2.3 and 3.5 h, respectively. Elimination of these two metabolites in urine. averaged 50 and 1 0%, respectively.
引用
收藏
页码:968 / 971
页数:4
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