ALCOHOL SENSITIVITY AND SMOKING HISTORY IN MEN AND WOMEN

被引:76
作者
MADDEN, PAF
HEATH, AC
STARMER, GA
WHITFIELD, JB
MARTIN, NG
机构
[1] UNIV SYDNEY, DEPT PHARMACOL, SYDNEY, NSW, AUSTRALIA
[2] ROYAL PRINCE ALFRED HOSP, DEPT BIOCHEM, SYDNEY, NSW, AUSTRALIA
[3] QUEENSLAND INST MED RES, BRISBANE, QLD, AUSTRALIA
关键词
ALCOHOL INTOXICATION; ALCOHOL CHALLENGE; SMOKING;
D O I
10.1111/j.1530-0277.1995.tb01588.x
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Many studies have found genetic effects to contribute to alcoholism risk in both men and women. Based on preliminary evidence for shared genetic risk between smoking and drinking problems, a reanalysis of alcohol challenge data on 412 Australian twins was performed to explore the possibility that smoking may diminish or moderate the intoxicating effects of alcohol. We found history of smoking to be strongly associated with self-reported intoxication after alcohol challenge in women (women: r = -0.44 +/- 0.08; men: r = -0.21 +/- 0.08), comparable with self-reported average weekly consumption of alcohol, which was more strongly associated in men (women: r = -0.37 +/- 0.07; men: r = -0.54 +/- 0.06). Structural equation model-fitting indicated a strong association between heavy drinking and smoking, but the association between smoking and postalcohol intoxication remained even when the effects of heavy drinking were controlled for. These results prompt the question of whether smoking cigarettes directly influences the transition from moderate to excessive use of alcohol by diminishing feelings of alcohol intoxication.
引用
收藏
页码:1111 / 1120
页数:10
相关论文
共 54 条
[1]   EEG, AUTONOMIC AND SUBJECTIVE CORRELATES OF THE RISK FOR ALCOHOLISM [J].
BAUER, LO ;
HESSELBROCK, VM .
JOURNAL OF STUDIES ON ALCOHOL, 1993, 54 (05) :577-589
[2]  
Bollen KA., 2014, STRUCTURAL EQUATIONS, DOI [10.1007/s11336-013-9335-3, DOI 10.1002/9781118619179]
[3]   GENETIC INFLUENCE ON SMOKING - A STUDY OF MALE TWINS [J].
CARMELLI, D ;
SWAN, GE ;
ROBINETTE, D ;
FABSITZ, R .
NEW ENGLAND JOURNAL OF MEDICINE, 1992, 327 (12) :829-833
[4]  
CEDERLOF R, 1971, ACTA MED SCAND, V523, P9
[5]  
COLLINS AC, 1989, PROG BRAIN RES, V79, P137
[6]  
DEFIEBRE CM, 1991, ALCOHOL CLIN EXP RES, V15, P270
[7]  
DEFIEBRE CM, 1992, J PHARMACOL EXP THER, V261, P173
[8]   BEHAVIORAL DESENSITIZATION TO NICOTINE IS ENHANCED DIFFERENTIALLY BY ETHANOL IN LONG-SLEEP AND SHORT-SLEEP MICE [J].
DEFIEBRE, CM ;
COLLINS, AC .
ALCOHOL, 1989, 6 (01) :45-51
[9]   ETHANOL-NICOTINE INTERACTIONS IN LONG-SLEEP AND SHORT-SLEEP MICE [J].
DEFIEBRE, CM ;
MARKS, MJ ;
COLLINS, AC .
ALCOHOL, 1990, 7 (03) :249-257
[10]   NICOTINE RESPONSE AND NICOTINIC RECEPTORS IN LONG-SLEEP AND SHORT-SLEEP MICE [J].
DEFIEBRE, CM ;
MEDHURST, LJ ;
COLLINS, AC .
ALCOHOL, 1987, 4 (06) :493-501