THE RIPOSTATINS, NOVEL INHIBITORS OF EUBACTERIAL RNA-POLYMERASE ISOLATED FROM MYXOBACTERIA

被引：64

作者：

IRSCHIK, H ^{[1
]}

AUGUSTINIAK, H ^{[1
]}

GERTH, K ^{[1
]}

HOFLE, G ^{[1
]}

REICHENBACH, H ^{[1
]}

机构：

[1] GESELL BIOTECHNOL FORSCH MBH,DEPT CHEM NAT PROD,D-38124 BRAUNSCHWEIG,GERMANY

来源：

JOURNAL OF ANTIBIOTICS | 1995年 / 48卷 / 08期

关键词：

D O I：

10.7164/antibiotics.48.787

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A new antibiotic, ripostatin, was isolated from the culture supernatant of the myxobacterium, Sorangium cellulosum strain So ce377. It is a macrocyclic lactone carbonic acid containing an unsubstituted phenyl ring in a side chain. The antibiotic acts especially on Staphylococcus aureus, but seems not to penetrate most bacteria. The MIC values are in the range of 1 mu g/ml. Ripostatin is an inhibitor of eubacterial RNA polymerase. It interferes with the initiation of RNA synthesis.

引用

页码：787 / 792

页数：6

共 7 条

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