SIMPLE HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC METHOD FOR THE SEPARATION OF 3,6-DIACETYLMORPHINE HYDROCHLORIDE (HEROIN) AND HYDROLYSIS PRODUCTS

被引：43

作者：

POOCHIKIAN, GK

CRADOCK, JC

机构：

[1] Pharmaceutical Resources Branch, Developmental Therapeutics Program, NIH, Bethesda, MD 20014, Bldg. 37

来源：

JOURNAL OF CHROMATOGRAPHY | 1979年 / 171卷 / APR期

关键词：

D O I：

10.1016/S0021-9673(01)95317-8

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The application of reversed-phase high-performance liquid chromatography to the measurement of 3,6-diacetylmorphine (DAM) hydrochloride and its degradation products was described. This method was applied to study the kinetics of DAM hydrolysis at 26 .+-. 0.1.degree. and 48 .+-. 0.1.degree.. DAM hydrolysis involved a 2-step 1st-order sequential mechanism between pH 3-8.6. The 1st-order rate constants of each step at all pH levels were determined. The pH rate profile was constructed from kinetic measurements and demonstrated that stability of DAM hydrochloride solutions was optimal at pH 4.3. This information was applied to the development of parenteral dosage forms of DAM hydrochloride.

引用

页码：371 / 376

页数：6

共 17 条

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