QUANTITATION OF BLOOD-BRAIN-BARRIER DEFECT BY MAGNETIC-RESONANCE-IMAGING AND GADOLINIUM-DTPA IN PATIENTS WITH MULTIPLE-SCLEROSIS AND BRAIN-TUMORS

被引:340
作者
LARSSON, HBW
STUBGAARD, M
FREDERIKSEN, JL
JENSEN, M
HENRIKSEN, O
PAULSON, OB
机构
[1] GENTOFTE HOSP,DEPT NEUROL,DK-2900 COPENHAGEN,DENMARK
[2] UNIV COPENHAGEN,RIGSHOSP,DEPT NEUROL,DK-2100 COPENHAGEN,DENMARK
关键词
D O I
10.1002/mrm.1910160111
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
In this study quantitation of the degree of deficiency of the blood‐brain barrier (BBB) in patients with multiple sclerosis or brain tumors, by using MRI, is shown to be possible. As a measure of permeability of the BBB to Gadolinium‐DTPA (Gd‐DTPA) the flux per unit of distribution volume per unit of brain mass was used. This quantity was found by introducing the longitudinal relaxation rate (R1) as a measure of concentration of Gd‐DTPA in the brain tissue in the mathematical model for the transcapillary transport over the BBB. High accordance between the observed data points and the model was found, and the results were comparable to results obtained from similar studies using positron emission tomography. The improved possibility of quantitating the defect of the BBB by MRI may give new information about pathogenesis or etiology, and leads to improved methods in monitoring the efficacy of treatments in intracranial diseases. © 1990 Academic Press, Inc. Copyright © 1990 Wiley‐Liss, Inc., A Wiley Company
引用
收藏
页码:117 / 131
页数:15
相关论文
共 26 条
[1]   HIGH-RESOLUTION COMPUTED-TOMOGRAPHY IN MULTIPLE-SCLEROSIS [J].
BARRETT, L ;
DRAYER, B ;
SHIN, C .
ANNALS OF NEUROLOGY, 1985, 17 (01) :33-38
[2]  
BRAUNSCHWEIGER P G, 1986, Magnetic Resonance Imaging, V4, P335, DOI 10.1016/0730-725X(86)91043-X
[3]  
BROMAN T, 1947, ACTA PSYCHIATR NEU S, V46, P58
[4]   PERMEABILITY OF CAPILLARIES IN VARIOUS ORGANS AS DETERMINED BY USE OF INDICATOR DIFFUSION METHOD [J].
CRONE, C .
ACTA PHYSIOLOGICA SCANDINAVICA, 1963, 58 (04) :292-&
[5]   GADOLINIUM-DTPA AS A CONTRAST AGENT IN MR IMAGING - THEORETICAL PROJECTIONS AND PRACTICAL OBSERVATIONS [J].
GADIAN, DG ;
PAYNE, JA ;
BRYANT, DJ ;
YOUNG, IR ;
CARR, DH ;
BYDDER, GM .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1985, 9 (02) :242-251
[6]   MULTIPLE-SCLEROSIS DISEASE-ACTIVITY CORRELATES WITH GADOLINIUM-ENHANCED MAGNETIC-RESONANCE-IMAGING [J].
GONZALEZSCARANO, F ;
GROSSMAN, RI ;
GALETTA, S ;
ATLAS, SW ;
SILBERBERG, DH .
ANNALS OF NEUROLOGY, 1987, 21 (03) :300-306
[7]   A KINETIC EVALUATION OF BLOOD-BRAIN-BARRIER PERMEABILITY IN HUMAN-BRAIN TUMORS WITH [GA-68] EDTA AND POSITRON COMPUTED-TOMOGRAPHY [J].
HAWKINS, RA ;
PHELPS, ME ;
HUANG, SC ;
WAPENSKI, JA ;
GRIMM, PD ;
PARKER, RG ;
JUILLARD, G ;
GREENBERG, P .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1984, 4 (04) :507-515
[8]   SIMPLIFIED, NONINVASIVE PET MEASUREMENT OF BLOOD-BRAIN-BARRIER PERMEABILITY [J].
IANNOTTI, F ;
FIESCHI, C ;
ALFANO, B ;
PICOZZI, P ;
MANSI, L ;
POZZILLI, C ;
PUNZO, A ;
DELVECCHIO, G ;
LENZI, GL ;
SALVATORE, M ;
CONFORTI, P .
JOURNAL OF COMPUTER ASSISTED TOMOGRAPHY, 1987, 11 (03) :390-397
[9]   BLOOD-BRAIN AND BLOOD SPINAL-CORD BARRIER PERMEABILITY DURING THE COURSE OF EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS IN THE RAT [J].
JUHLER, M ;
BARRY, DI ;
OFFNER, H ;
KONAT, G ;
KLINKEN, L ;
PAULSON, OB .
BRAIN RESEARCH, 1984, 302 (02) :347-355
[10]  
KAPPOS L, 1988, DIAGNOSTIC IMAGING S, P36