EFFECT OF 1-ALPHA-HYDROXYVITAMIN-D3 ON OSTEOPOROSIS IN RATS INDUCED BY OOPHORECTOMY

被引：61

作者：

LINDGREN, JU

LINDHOLM, TS

机构：

[1] Department of Orthopaedic Surgery, Huddinge University Hospital, Karolinska Institute, Stockholm

来源：

CALCIFIED TISSUE INTERNATIONAL | 1979年 / 27卷 / 02期

关键词：

Osteoporosis; Ovary; Rat; Vitamin D;

D O I：

10.1007/BF02441179

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Fifty adult female rats were used to study the effect of 1-alpha-hydroxyvitamin D3 (1α-OH-D3)on bone after oophorectomy. The experimental period was 6 months. At the end of the experiment the femurs and the tibias were investigated for bone mass and composition. Significant signs of osteopenia occurred as a result of oophorectomy. The treatment with 1α-OH-D3 induced only minor changes in blood chemistry but increased bone mass significantly. The findings support the view that 1α-OH-D3 may be a valuable tool in the treatment of osteoporosis resulting from ovarian insufficiency. © 1979 Springer-Verlag.

引用

页码：161 / 164

页数：4

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