ANTIBIOTIC GE2270-A - A NOVEL INHIBITOR OF BACTERIAL PROTEIN-SYNTHESIS .1. ISOLATION AND CHARACTERIZATION

被引:145
作者
SELVA, E [1 ]
BERETTA, G [1 ]
MONTANINI, N [1 ]
SADDLER, GS [1 ]
GASTALDO, L [1 ]
FERRARI, P [1 ]
LORENZETTI, R [1 ]
LANDINI, P [1 ]
RIPAMONTI, F [1 ]
GOLDSTEIN, BP [1 ]
BERTI, M [1 ]
MONTANARO, L [1 ]
DENARO, M [1 ]
机构
[1] UNIV BOLOGNA, DEPT EXPTL PATHOL, I-40126 BOLOGNA, ITALY
关键词
D O I
10.7164/antibiotics.44.693
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A novel antibiotic, GE2270 A, was isolated from the fermentation broth of a strain of Planobispora rosea. The product was found to inhibit bacterial protein synthesis. Structural characteristics showed similarities between GE2270 A and thiazolyl peptides such as micrococcin which is known to inhibit protein synthesis by acting directly on the ribosome. Despite this similarity GE2270 A showed functional analogy to kirromycin-like antibiotics and pulvomycin, as its molecular target was found to be elongation factor Tu (EF-Tu). GE2270 A is active against Gram-positive microorganism and anaerobes and differs from the other EF-Tu inhibitors in its spectrum of antimicrobial activity.
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页码:693 / 701
页数:9
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